| No | Size | Price | Availability | |
| ARP867P-31 | 50ul | 1500.00 | In Stock |  |
| ARP867P-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 867 |
| Isotype: | / | Swiss Prot: | P22681 |
| purity: | Affinity purification |
| Background: |
| The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 120 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr774 of human c-Cbl |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | C-CBL, CBL2, RNF55 |
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