| No | Size | Price | Availability | |
| ARP8737-12 | 50ul | 1500.00 | In Stock |  |
| ARP8737-12 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8737 |
| Isotype: | / | Swiss Prot: | Q13546 |
| purity: | Peptide affinity purification |
| Background: |
| The receptor-interacting protein (RIP) family of serine-threonine kinases (RIP, RIP2, RIP3, and RIP4) are important regulators of cellular stress that trigger pro-survival and inflammatory responses through the activation of NF-κB, as well as pro-apoptotic pathways (1). In addition to the kinase domain, RIP contains a death domain responsible for interaction with the death domain receptor Fas and recruitment to TNF-R1 through interaction with TRADD (2,3). RIP-deficient cells show a failure in TNF-mediated NF-κB activation, making the cells more sensitive to apoptosis (4,5). RIP also interacts with TNF-receptor-associated factors (TRAFs) and can recruit IKKs to the TNF-R1 signaling complex via interaction with NEMO, leading to IκB phosphorylation and degradation (6,7). Overexpression of RIP induces both NF-κB activation and apoptosis (2,3). Caspase-8-dependent cleavage of the RIP death domain can trigger the apoptotic activity of RIP (8). |
| Reactivity | Human |
| Tested applications | IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 78 kDa |
| Recommended Dilutions |
IHC 10 ug/mL
|
| Immunogen | A synthetic peptide corresponding to 14 amino acids at C-terminus of human RIPK1 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | FLJ39204, RIP, RIP1 |
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