CRTC2 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP200186-13 50ul 1500.00 In Stock
ARP200186-13 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 200186
Isotype: / Swiss Prot: Q53ET0
purity: Peptide affinity purification
Background:
Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic β-cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes β-cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling (1). The protein CRTC2 (CREB-regulated transcription coactivator 2)/TORC2 (transducer of regulated CREB activity 2) functions as a CREB co-activator (2,3) and is implicated in mediating the effects of these two pathways (4). In quiescent cells, CRTC2/TORC2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of CRTC2/TORC2 and its dissociation from 14-3-3 proteins. Dephosphorylated CRTC2/TORC2 enters the nucleus to promote CREB-dependent transcription. CRTC2/TORC2 plays a key role in the regulation of hepatic gluconeogenic gene transcription in response to hormonal and energy signals during fasting (5).
Reactivity Human, Mouse, Rat
Tested applications WB IHC ELISA IF
Clonality Polyclonal Antibody
Calculated MW 80 kDa
Recommended Dilutions
WB 1-2 ug/mL
IHC 2.5 ug/mL
IF 20 ug/mL
Immunogen A synthetic peptide corresponding to 16 amino acids at C-terminus of human CRTC2
Storage Store at 4°C. For long term storage store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Synonym RP11-422P24.6, TORC2
This product is for research use only, not for diagnostic or therapeutic use!

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