ATXN10/SCA10 Rabbit Polyclonal Antibody
No Size Price Availability  
YRP11811-01 50ul 1500.00 In Stock
YRP11811-01 100ul 2000.00 In Stock
  • Details
  • FAQs
  • Manual
Source: Rabbit Gene Id:
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic peptide derived from human ATXN10/SCA10
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym Ataxin 10, Ataxin-10, ATX10_HUMAN, Atxn10, Brain protein E46 homolog, E46L, FLJ37990, HUMEEP, Like mouse brain protein E46, SCA10, Spinocerebellar ataxia 10, Spinocerebellar ataxia type 10 protein.
This product is for research use only, not for diagnostic or therapeutic use!

backtop
QQ
service center
Contact Us