| No | Size | Price | Availability | |
| ARP10411-61 | 50ul | 1500.00 | In Stock |  |
| ARP10411-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10411 |
| Isotype: | IgG | Swiss Prot: | O95398 |
| purity: | Affinity purification |
| Background: |
| EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 100,110 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | cAMP-regulated guanine nucleotide exchange factor I, cAMP-GEFI, Exchange factor directly activated by cAMP 1, Epac 1, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP |
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