| No | Size | Price | Availability | |
| ARP4254-61 | 50ul | 1500.00 | In Stock |  |
| ARP4254-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4254 |
| Isotype: | IgG | Swiss Prot: | P21583 |
| purity: | Affinity purification |
| Background: |
| Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 25-38 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
|
| Immunogen | Peptide sequence around aa.265~269(E-K-E-R-E) derived from Human SCF. |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SF, MGF, FPH2, KL-1, Kitl |
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