| No | Size | Price | Availability | |
| ARP9232-61 | 50ul | 1500.00 | In Stock |  |
| ARP9232-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9232 |
| Isotype: | IgG | Swiss Prot: | O95997 |
| purity: | Affinity chromatography |
| Background: |
| securin Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. |
| Reactivity | Human |
| Tested applications | WB IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 30 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human PTTG1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EAP1, Esp1-associated protein, ESP1-associated protein 1, hPTTG, MGC126883, MGC138276, pituitary tumor-transforming 1, Pituitary tumor-transforming gene 1 protein, PTTG, PTTG1, Securin, Tumor-transforming protein 1, TUTR1 |
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