| No | Size | Price | Availability | |
| ARP2261-61 | 50ul | 1500.00 | In Stock |  |
| ARP2261-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2261 |
| Isotype: | IgG | Swiss Prot: | P22607 |
| purity: | Affinity chromatography |
| Background: |
| FGFR3 a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with thanatophoric dysplasia (TD), craniosynostosis Adelaide type, many craniosynostotic syndromes and bone malformations. Three splice-variant isoforms have been described. Activating point mutations cause dwarfism, including achondroplasia, hypochrondroplasia and thanatophoric dysplasia, and facial and other morphogenetic disorders, including Crouzon syndrome, craniosynostosis Adelaide type, San Diego skeletal displasia and Muenke syndrome. Translocations t(4;14) involving the IgH region are common in multiple myeloma and frequently involve FGFR3. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 95 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human FGFR3 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ACH, achondroplasia, thanatophoric dwarfism, CD333, CEK2, FGFR-3, FGFR3, Fibroblast growth factor receptor 3, HSFGFR3EX, hydroxyaryl-protein kinase, JTK4, tyrosine kinase JTK4 |
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