| No | Size | Price | Availability | |
| ARP843-61 | 50ul | 1500.00 | In Stock |  |
| ARP843-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 843 |
| Isotype: | IgG | Swiss Prot: | Q92851-2/4 |
| purity: | Affinity chromatography |
| Background: |
| Casp10 Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Belongs to the peptidase C14A family. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. 6 isoforms of the human protein are produced by alternative splicing. |
| Reactivity | Human |
| Tested applications | WB IHC IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 60 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human Caspase 10 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ALPS2, Apoptotic protease Mch-4, CASP-10, CASP10, CASPA, caspase 10, apoptosis-related cysteine peptidase, caspase 10, apoptosis-related cysteine protease, Caspase-10, Caspase-10 subunit p12, Caspase-10 subunit p23/17, FADD-like ICE2, FAS-associated death |
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