| No | Size | Price | Availability | |
| ARP5925P-03 | 50ul | 1500.00 | In Stock |  |
| ARP5925P-03 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5925 |
| Isotype: | IgG | Swiss Prot: | P06400 |
| purity: | Affinity purification |
| Background: |
| The retinoblastoma tumor suppressor protein, Rb, regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase, and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation (6). Specificity of different CDK/cyclin complexes has been observed in vitro (6-8) and cyclin D1 is required for Ser780 phosphorylation in vivo (9). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 102kDa |
| Recommended Dilutions |
WB 1:500 - 1:2000
IF 1:50 - 1:200
|
| Immunogen | A phospho specific peptide corresponding to residues surrounding S811 of_+E_human RB |
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | RB1, RB, pRb, OSRC, pp110, p105-Rb |
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