| No | Size | Price | Availability | |
| ARP5925P-02 | 50ul | 1500.00 | In Stock |  |
| ARP5925P-02 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5925 |
| Isotype: | IgG | Swiss Prot: | P06400 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 102 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IF 1:50-1:200
|
| Immunogen | A phospho specific peptide corresponding to residues surrounding S795 of human RB |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | RB, pRb, OSRC, pp110, p105-Rb |
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