
| Source: | Rabbit | Gene Id: | 1200 | 
| Isotype: | IgG | Swiss Prot: | O14773 | 
| purity: | Affinity purification | 
| Background: | 
| This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. | 
| Reactivity | Human, Mouse, Rat | 
| Tested applications | WB IHC | 
| Clonality | Polyclonal Antibody | 
| Calculated MW | 61kDa | 
| Recommended Dilutions | WB 1:500 - 1:2000 IHC 1:50 - 1:200 | 
| Immunogen | A recombinant protein of human TPP1 | 
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | 
| Synonym | CLN2, GIG1, LPIC, TPP-1 | 
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