AKT1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP207-01 50ul 1500.00 In Stock
ARP207-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 207
Isotype: IgG Swiss Prot: P31749
purity: Affinity purification
Background:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Reactivity Human, Mouse, Rat
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 60 kDa
Recommended Dilutions
WB 1:500-1:1000
IHC 1:50-1:100
Immunogen A synthetic peptide of human AKT1
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA
This product is for research use only, not for diagnostic or therapeutic use!

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