PRKAB1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP5564-01 50ul 1500.00 In Stock
ARP5564-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5564
Isotype: IgG Swiss Prot: Q9Y478
purity: Affinity purification
Background:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Reactivity Human, Mouse, Rat
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 38 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A recombinant protein of human PRKAB1
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym AMPK, HAMPKb
This product is for research use only, not for diagnostic or therapeutic use!

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