FLNB Rabbit Polyclonal Antibody
No Size Price Availability  
ARP2317-01 50ul 1500.00 In Stock
ARP2317-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 2317
Isotype: IgG Swiss Prot: O75369
purity: Affinity purification
Background:
Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (alpha-actinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as beta integrins, Rho/Rac/Cdc42, PKC, and the insulin receptor, primarily through the carboxy-terminal dimerization domain (1-3). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Filamin A is phosphorylated by PAK1 at Ser2152, which is required for PAK1-mediated actin cytoskeleton reorganization (4).
Reactivity Human, Mouse, Rat
Tested applications WB IF
Clonality Polyclonal Antibody
Calculated MW 278 kDa
Recommended Dilutions
WB 1:500-1:1000
IF 1:20-1:50
Immunogen A synthetic peptide of human FLNB
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym ABP-278, AOI, DKFZp686A1668, DKFZp686O033, FH1, FLN1L, LRS1, SCT, TABP, TAP
This product is for research use only, not for diagnostic or therapeutic use!

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