| No | Size | Price | Availability | |
| ARP51548-01 | 50ul | 1500.00 | In Stock |  |
| ARP51548-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 51548 |
| Isotype: | IgG | Swiss Prot: | Q8N6T7 |
| purity: | Affinity purification |
| Background: |
| SIRT6, also named as SIR2L6, belongs to the sirtuin family. SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. It has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. It is required for genomic stability. And it is required for normal IGF1 serum levels and normal glucose homeostasis. It modulates cellular senescence and apoptosis. It regulates the production of TNF protein. SIRT6 acts as a histone deacetylase to directly repress multiple glycolytic genes. SIRT6 also functions as a corepressor of the transcription factor Hif1α. Loss of SIRT6 increases glycolysis and diminishes mitochondrial respiration. SIRT6 plays a key role in regulating glucose homeostasis. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 36 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
|
| Immunogen | A fusion protein of human SIRT6 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SIRT6, SIR2L6 |
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