| No | Size | Price | Availability | |
| ARP2034-01 | 50ul | 1500.00 | In Stock |  |
| ARP2034-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2034 |
| Isotype: | IgG | Swiss Prot: | Q99814 |
| purity: | Affinity purification |
| Background: |
| Hypoxia-inducible factor (HIF) is essential for the cellular response to hypoxia (1,2). Under normoxia conditions, the α subunit of HIF is ubiquitinated by von Hippel-Lindau (VHL) protein and is degraded in the ubiquitin/proteasome pathway (1,2). Hypoxia inhibits the degradation of the α subunit, which leads to its stabilization (1,2). HIF, in turn, regulates the transcription of a variety of genes that respond to hypoxia conditions (1,2). There are several isoforms of the HIF α subunit (2). Studies have found that HIF-1α and HIF-2α expression is increased in some human cancers (2). HIF-1α has both pro- and anti-proliferative activities, whereas HIF-2α does not possess anti-proliferative activity (2). Therefore, HIF-2α likely plays an important role in tumorigenesis (2,3). |
| Reactivity | Human |
| Tested applications | WB FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 96 kDa |
| Recommended Dilutions |
WB 1:200-1:500
FC 1:20-1:50
|
| Immunogen | A synthetic peptide of human HIF2A |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EPAS1, BHLHE73, HIF2A, MOP2, PASD2 |
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