| No | Size | Price | Availability | |
| ARP5321-01 | 50ul | 1500.00 | In Stock |  |
| ARP5321-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5321 |
| Isotype: | IgG | Swiss Prot: | P47712 |
| purity: | Affinity purification |
| Background: |
| Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid (1). cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity (1). Calcium binding to the amino-terminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane (2). Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at Ser505 (3,4) and Ser727 (5) stimulates its catalytic activity. |
| Reactivity | Human |
| Tested applications | WB IHC IF FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 85 kDa |
| Recommended Dilutions |
WB 1:200-1:500
IHC 1:50-1:100
IF 1:20-1:50
FC 1:20-1:50
|
| Immunogen | A synthetic peptide of human cPLA2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Lysophospholipase, PLA2G4, CPLA2, PLA2G4A |
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