| No | Size | Price | Availability | |
| ARP4684-01 | 50ul | 1500.00 | In Stock |  |
| ARP4684-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4684 |
| Isotype: | IgG | Swiss Prot: | P13591 |
| purity: | Affinity purification |
| Background: |
| Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modi?ed by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 95kD |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
FC 1:20-1:100
|
| Immunogen | A recombinant protein of human NCAM1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CD56, MSK39, NCAM |
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