Source: | Rabbit | Gene Id: | 23608 |
Isotype: | IgG | Swiss Prot: | |
purity: | Purified by Protein A. |
Background: |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | / |
Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
Immunogen | KLH conjugated synthetic peptide derived from human MKRN1/RNF61 |
Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
Synonym | RING finger protein 61, E3 ubiquitin-protein ligase makorin-1, Makorin, Makorin ring finger protein 1, MKRN 1, MKRN-1, mkrn1, MKRN1_HUMAN, Ring finger protein 1, RNF61. |
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