| No | Size | Price | Availability | |
| YRP09239-01 | 50ul | 1500.00 | In Stock |  |
| YRP09239-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8804 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. CREG (cellular repressor of E1A-stimulated genes) is a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. CREG was initially isolated in a yeast two-hybrid screen due to its interaction with the TATA-binding protein, TBP. Binding sites for E2F, a key transcriptional reg-ulator of cell cycle progression, are required for repression of the adeno-virus E2 promoter by CREG, and CREG was shown to inhibit activation by E2F. CREG is broadly expressed in adult tissues and is regulated during embryonic development. CREG is a secreted glycoprotein which enhances differentiation of mouse embryonic stem cells and human NTERA-2 cells. CREG activity may contribute to the transcriptional control of cell growth and differentiation. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human CREG1 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | Cellular repressor of E1A stimulated genes 1, Cellular repressor of E1A-stimulated genes 1, CREG, CREG1, CREG1_HUMAN, Protein CREG1. |
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