| No | Size | Price | Availability | |
| YRP06604-01 | 50ul | 1500.00 | In Stock |  |
| YRP06604-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2044 |
| Isotype: | IgG | Swiss Prot: | P54756 |
| purity: | Purified by Protein A. |
| Background: |
| Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human EphA5/Eph receptor A5 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | EK7, CEK7, EHK1, HEK7, EHK-1, TYRO4, Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EPH-like kinase 7, EPHA5, BSK |
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