Phospho-Girdin (Ser1417) Rabbit Polyclonal Antibody
No Size Price Availability  
YRP06470P-01 50ul 1500.00 In Stock
YRP06470P-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 55704
Isotype: IgG Swiss Prot: Q3V6T2
purity: Purified by Protein A.
Background:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Reactivity Human, Mouse, Rat
Tested applications IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic phosphopeptide derived from human Girdin around the phosphorylation site of Ser1417
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym APE, GIV, GRDN, HkRP1, GIRDIN, KIAA1212, Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament, Hook-related protein 1, CCDC88A
This product is for research use only, not for diagnostic or therapeutic use!

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