BRCC45 Rabbit Polyclonal Antibody
No Size Price Availability  
YRP05715-01 50ul 1500.00 In Stock
YRP05715-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 9577
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic peptide derived from human BRCC45
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym Brain and reproductive organ expressed TNFRSF1A modulator, BRCA1/BRCA2 containing complex subunit 4, BRCA1/BRCA2 containing complex subunit 45, BRCC4, BRCC45, BRE_HUMAN.
This product is for research use only, not for diagnostic or therapeutic use!

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