| No | Size | Price | Availability | |
| YRP05638P-01 | 50ul | 1500.00 | In Stock |  |
| YRP05638P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6857 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human SYT1 around the phosphorylation site of Thr202 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | Syt1phospho T202, Synaptotagmin II Thr202, SYT1_HUMAN, DKFZp781D2042, P65, SVP65, Synaptotagmin I, Synaptotagmin II, Synaptotagmin IV, Synaptotagmin V, SYT 1, SYT, SYT1, SYT2, SYT3, SYT4, SYT5, SytI. |
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