| No | Size | Price | Availability | |
| YRP05615P-01 | 50ul | 1500.00 | In Stock |  |
| YRP05615P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7249 |
| Isotype: | IgG | Swiss Prot: | P49815 |
| purity: | Purified by Protein A. |
| Background: |
| In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1798 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | LAM, TSC4, PPP1R160, Tuberin, Tuberous sclerosis 2 protein, TSC2 |
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