| No | Size | Price | Availability | |
| YRP05542P-01 | 50ul | 1500.00 | In Stock |  |
| YRP05542P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5170 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human PDPK1 around the phosphorylation site of Ser393 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | PDPK1phospho S393, 3 phosphoinositide dependent protein kinase 1, hPDK 1, hPDK1, MGC20087 MGC35290, PDK 1, PDPK 1, PDPK1, PkB kinase, PkB kinase like gene 1, PkB like 1, PkB like, PRO0461, PDPK1_HUMAN. |
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