| No | Size | Price | Availability | |
| YRP05479P-01 | 50ul | 1500.00 | In Stock |  |
| YRP05479P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4155 |
| Isotype: | IgG | Swiss Prot: | P02686 |
| purity: | Purified by Protein A. |
| Background: |
| The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human MBP around the phosphorylation site of Thr232 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein |
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