Phospho-Separase (Ser1073) Rabbit Polyclonal Antibody
No Size Price Availability  
YRP05309P-01 50ul 1500.00 In Stock
YRP05309P-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 9700
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
Reactivity Human
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic phosphopeptide derived from human ESPL1 around the phosphorylation site of Ser1073
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym Caspase like protein ESPL1, ESP 1, ESP1, ESP-1, ESPL 1, ESPL1, ESPL-1, Extra spindle poles like 1, Extra spindle poles like 1 protein, Separin, Similar to fission yeast cut1and gene, SSE, Separase, ESPL1_HUMAN.
This product is for research use only, not for diagnostic or therapeutic use!

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