| No | Size | Price | Availability | |
| YRP04600-01 | 50ul | 1500.00 | In Stock |  |
| YRP04600-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1282 |
| Isotype: | IgG | Swiss Prot: | P02462 |
| purity: | Purified by Protein A. |
| Background: |
| Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | ICH, HANAC, POREN1, arresten, Collagen alpha-1(IV) chain, COL4A1 |
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