| No | Size | Price | Availability | |
| YRP03828-01 | 50ul | 1500.00 | In Stock |  |
| YRP03828-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4204 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3 and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human MeCP2 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | AUTSX 3, AUTSX3, Mbd 5, Mbd5, MECP 2, MECP-2, MeCP 2 protein, Methyl CpG binding protein 2 Rett syndrome, Methyl CpG binding protein 2, MRX 16, MRX 79, MRX16, MRX79, MRXS 13, MRXS13, MRXSL, PPMX, RTS, RTT, WBP 10, WBP10. MECP2_HUMAN |
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