| No | Size | Price | Availability | |
| YRP03781-01 | 50ul | 1500.00 | In Stock |  |
| YRP03781-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3020 |
| Isotype: | IgG | Swiss Prot: | P84243 |
| purity: | Purified by Protein A. |
| Background: |
| Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic acetylpeptide derived from human Histone H3 around acetylation site of Lys9 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | H3F3, H3.3A, Histone H3.3, H3F3A, PP781 |
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