| No | Size | Price | Availability | |
| YRP03639-01 | 50ul | 1500.00 | In Stock |  |
| YRP03639-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6478, 6477 |
| Isotype: | IgG | Swiss Prot: | O43255, Q8IUQ4 |
| purity: | Purified by Protein A. |
| Background: |
| Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human SIAH2 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | Seven in Absentia Homolog 2, Ubiquitin Ligase Siah2, SIAH2_HUMAN, E3 ubiquitin-protein ligase SIAH2, Seven in absentia homolog 2, Siah-2, hSiah2, Siah-1, Siah-1a, E3 ubiquitin-protein ligase SIAH1, Seven in absentia homolog 1. |
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