| No | Size | Price | Availability | |
| YRP03258P-01 | 50ul | 1500.00 | In Stock |  |
| YRP03258P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4040 |
| Isotype: | IgG | Swiss Prot: | O75581 |
| purity: | Purified by Protein A. |
| Background: |
| Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). |
| Reactivity | Human, Mouse |
| Tested applications | IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | ADCAD2, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6 |
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