| No | Size | Price | Availability | |
| YRP02991-01 | 50ul | 1500.00 | In Stock |  |
| YRP02991-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 117144 |
| Isotype: | IgG | Swiss Prot: | Q8NEC5 |
| purity: | Purified by Protein A. |
| Background: |
| Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human CATSPER |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | SPGF7, CATSPER, Cation channel sperm-associated protein 1, CatSper1, hCatSper |
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