| No | Size | Price | Availability | |
| YRP02665-01 | 50ul | 1500.00 | In Stock |  |
| YRP02665-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 375611 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| SLC26A5 (Solute carrier family 26, member 5) is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. It acts as a motor protein that converts auditory stimuli to length changes in outer hair cells. It is a bidirectional voltage-to-force converter which uses cytoplasmic anions as extrinsic voltage sensors. The anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. This translocation triggers conformational changes in the protein that alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). It acts as an incomplete transporter since it moves anions across the membrane, but does not allow the anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the anion-binding site. Mutations in SLC26A5 have been associated with non-syndromic hearing loss. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB FC IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
FC 1:20-1:100
|
| Immunogen | KLH conjugated synthetic peptide derived from human Slc26a5 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | Prestin, Deafness neurosensory autosomal recessive 61, DFNB 61, DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES, Prestin motor protein, Prestin, S26A5_HUMAN, SLC26A5, Solute carrier family 26 member 5 prestin, Solute carrier family 26 member 5. |
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