| No | Size | Price | Availability | |
| YRP00684-01 | 50ul | 1500.00 | In Stock |  |
| YRP00684-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 84447 |
| Isotype: | IgG | Swiss Prot: | Q86TM6 |
| purity: | Purified by Protein A. |
| Background: |
| Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IHC-F IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human SYVN1 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | DER3, HRD1, E3 ubiquitin-protein ligase synoviolin, Synovial apoptosis inhibitor 1, SYVN1, KIAA181 |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
