| No | Size | Price | Availability | |
| YRP02595-01 | 50ul | 1500.00 | In Stock |  |
| YRP02595-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5978 |
| Isotype: | IgG | Swiss Prot: | Q13127 |
| purity: | Purified by Protein A. |
| Background: |
| Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human NRSF |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | XBR, NRSF, RE1-silencing transcription factor, Neural-restrictive silencer factor, X2 box repressor, REST |
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