| No | Size | Price | Availability | |
| YRP02167-01 | 50ul | 1500.00 | In Stock |  |
| YRP02167-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 22943 |
| Isotype: | IgG | Swiss Prot: | O94907 |
| purity: | Purified by Protein A. |
| Background: |
| Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Reactivity | Human, Mouse, Rat, Dog |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human DKK1 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | SK, DKK-1, Dickkopf-related protein 1, Dickkopf-1, hDkk-1, DKK1, UNQ492/PRO18 |
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