| No | Size | Price | Availability | |
| YRP18149-01 | 50ul | 1500.00 | In Stock |  |
| YRP18149-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3556 |
| Isotype: | IgG | Swiss Prot: | Q9NPH3 |
| purity: | Purified by Protein A. |
| Background: |
| Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
|
| Immunogen | KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | IL1R3, C3orf13, IL-1RAcP, Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
