| No | Size | Price | Availability | |
| YRP15390-01 | 50ul | 1500.00 | In Stock |  |
| YRP15390-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 23432 |
| Isotype: | IgG | Swiss Prot: | Q8N6U8 |
| purity: | Purified by Protein A. |
| Background: |
| Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human GPR161 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | RE2, G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161 |
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