| No | Size | Price | Availability | |
| YRP01424-01 | 50ul | 1500.00 | In Stock |  |
| YRP01424-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 17199 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB FC IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
FC 1:20-1:100
|
| Immunogen | KLH conjugated synthetic peptide derived from mouse MC-1R |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | CMM5, MC1-R, MC1R, Melanocortin 1 receptor, Melanocortin 1 receptor alpha melanocyte stimulating hormone receptor, Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Melanotropin receptor, MSH-R, MSHR, MSHR_HUMAN, SHEP2. |
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