| No | Size | Price | Availability | |
| YRP13458-01 | 50ul | 1500.00 | In Stock |  |
| YRP13458-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2762 |
| Isotype: | IgG | Swiss Prot: | |
| purity: | Purified by Protein A. |
| Background: |
| GMD is a 372 amino acid protein that utilizes NADP as a cofactor to catalyze the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose. GMD mutations are involved in resistance to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis. The gene encoding GMD maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human GMDS |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | GDP D mannose dehydratase, GDP mannose 4 6 dehydratase, GDP-D-mannose dehydratase, GDP-mannose 4,6 dehydratase, GMD, Gmds, GMDS_HUMAN, OTTHUMP00000017756, OTTHUMP00000232770, SDR3E1, Short chain dehydrogenase/reductase family 3E member 1. |
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