| No | Size | Price | Availability | |
| YRP13100-01 | 50ul | 1500.00 | In Stock |  |
| YRP13100-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1161 |
| Isotype: | IgG | Swiss Prot: | Q13216 |
| purity: | Purified by Protein A. |
| Background: |
| Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human ERCC8/CSA |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | CSA, CKN1, UVSS2, DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8 |
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