DMP1 Rabbit Polyclonal Antibody
No Size Price Availability  
YRP12364-01 50ul 1500.00 In Stock
YRP12364-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 1758
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
DMP-1 is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone.
Reactivity Human
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic peptide derived from human DMP1
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym ARHP, ARHR, AV020965, Dentin matrix acidic phosphoprotein 1, Dentin matrix protein 1, DENTMAT, DMP 1, Dmp, MGC130441, PP, Serine rich acidic phosphoprotein, DMP1_HUMAN.
This product is for research use only, not for diagnostic or therapeutic use!

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