| No | Size | Price | Availability | |
| ARP920-01 | 50ul | 1500.00 | In Stock |  |
| ARP920-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 920 |
| Isotype: | IgG | Swiss Prot: | P01730 |
| purity: | Affinity purification |
| Background: |
| Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1). |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 55kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | Recombinant protein of human CD4 |
| Storage | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | CD4mu |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
