SIGLEC12 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP89858-01 50ul 1500.00 In Stock
ARP89858-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 89858
Isotype: IgG Swiss Prot: Q96PQ1
purity: Affinity purification
Background:
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
Reactivity Mouse
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 65kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Recombinant protein of human SIGLEC12
Storage Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym S2V, SLG, SIGLECL1, Siglec-XII
This product is for research use only, not for diagnostic or therapeutic use!

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