Source: | Rabbit | Gene Id: | 8647 |
Isotype: | IgG | Swiss Prot: | O95342 |
purity: | Affinity purification |
Background: |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. |
Reactivity | Human, Mouse |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 146kDa |
Recommended Dilutions |
WB 1:500-1:2000
|
Immunogen | Recombinant protein of human ABCB11 |
Storage | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | BSEP, PGY4, SPGP, ABC16, BRIC2, PFIC2, PFIC-2 |
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