| No | Size | Price | Availability | |
| ARP842-02 | 50ul | 1500.00 | In Stock |  |
| ARP842-02 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 842 |
| Isotype: | IgG | Swiss Prot: | P55211 |
| purity: | Affinity purification |
| Background: |
| Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family (1,2). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response (3-6). Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis (7-10). |
| Reactivity | Human, Mouse |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 46kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IF 1:50-1:100
|
| Immunogen | Recombinant protein of human CASP9 |
| Storage | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6 |
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