CASP3 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP836-03 50ul 1500.00 In Stock
ARP836-03 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 836
Isotype: IgG Swiss Prot: P42574
purity: Affinity purification
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Reactivity Human, Mouse, Rat
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 32kDa
Recommended Dilutions
WB 1:500-1:1000
IHC 1:50-1:100
Immunogen Recombinant protein of human CASP3
Storage Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym CPP32, SCA-1, CPP32B
This product is for research use only, not for diagnostic or therapeutic use!

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